Police officials said a suicide bomber rammed a truck packed with explosives into the checkpoint in the north Sinai city of El-Arish and gunmen then opened fire on the security post.
The Islamic State group's Egyptian branch in the Sinai Peninsula has carried out several such attacks over the past two years.
Eight people were also wounded in the attack, state newspaper al-Ahram reported on its website.
Militants have killed hundreds of soldiers and policemen since the 2013 military overthrow of former President Mohamed Morsi, which unleashed a bloody crackdown on his supporters.
Most of the attacks have taken place in the Sinai Peninsula, which borders Israel and the Palestinian Gaza Strip.
In November, a car bomb attack on a checkpoint in Sinai killed eight soldiers.
Truck bomb targets police in Egypt's troubled Sinai province
Truck bomb targets police in Egypt's troubled Sinai province
MENA
1 min read
A bomb has killed or injured over a dozen Egyptian security personnel during an attack on a police checkpoint in the country's restless Sinai province.
Egyptian security have been repeatedly targeted in Sinai [Getty]
A truck bomb attack on an Egyptian security checkpoint in the Sinai Peninsula killed at least eight policemen on Monday, officials and state media said.