Gaza's civil defence agency said an Israeli strike near Jabalia in the territory's north killed 33 people at a refugee camp overnight from Friday to Saturday.
Agency spokesman Mahmud Bassal announced "33 deaths and dozens of wounded", while a medical source at the Al-Awda hospital told AFP that it had registered 22 dead and 70 wounded after the strike on the Tal al-Zaatar camp for Palestinian refugees.
North Gaza has been hit hard by Israeli strikes throughout Friday as the military presses into Jabalia with reports of houses being blown up up as tanks push through residential areas.
Footage shared online showed what appeared to be residential buildings destroyed by blasts with reports that dozens of civilians have been killed by the destruction.
Hospitals in the north have urgently called for fuel and medical supplies as they are overwhelmed by the daily stream of wounded.
Meanwhile, Hamas have confirmed the killing of its leader Yahya Sinwar, one day after he was killed.
Israel's Prime Minister Benjamin Netanyahu said that the killing of Sinwar will not bring about an end to the year-long brutal war in Gaza.
Sinwar was killed by Israeli military in Rafah in southern Gaza, just months after Sinwar succeeded Ismail Haniyeh as the group’s leader.