Hamas' al-Qassam Brigades said its West Bank-based fighters killed an Israeli soldier at point-blank range near the settlement of Mehola in the Jordan Valley and "returned to their bases safely."
It said the operation came in retaliation for Israel's strike on a school where displaced Palestinians were sheltering in Gaza City on Saturday, which the civil defence service said had killed at least 90 people.
The Israeli military said it was pursuing the suspected assailants, blocking routes and conducting searches.