At least nine Palestinians, including two children and a woman, were killed at dawn on Saturday by Israeli shelling in and around Gaza's Khan Younis and in the Al-Nuseirat camp area, the official Palestinian news Wafa agency reported.
At least 15 others were also injured in the attacks, Wafa added.
Israeli forces were engaged in battles with Palestinian militants across central, south and north Gaza throughout Friday as civilians continued to flee to a shrinking safe area.
Al-Qassam and al-Quds Brigades were engaged in clashes with Israeli forces in al-Zeitoun in northern Gaza and in Tel al-Hawa in the south, local media reported.
The United Nations said tens of thousands of civilians have been on the move again this week from Deir el-Balah and the southern city of Khan Younis after Israeli military evacuation orders. It has pushed thousands more into already overcrowded so-called 'safe-zones' which constitute only 10 percent of the enclave.
The war has displaced about 90 percent of Gaza's population, often multiple times, leaving them deprived of shelter, clean water and other essentials as disease spreads.
An Israeli air force control tower in Mount Meron, northern Israel, was targeted by Hezbollah rockets, according to Israel media, with a direct hit from one missile to the facility. Israel has carried out a series of strikes on southern Lebanon over the past hours.
The White House said ceasefire talks in Cairo were "constructive", despite reports that Israeli Prime Minister Netanyahu is refusing to back down on the key issue of leaving troops in Gaza.
Israel and Palestinian group Hamas have traded blame for failing to reach a deal after more than 10 months of war in the Gaza Strip.
(with Agencies)