The Israeli army has struck the UN's Al-Fakhoura school in an attack that has left 50 people dead according to an official from Gaza's health ministry.
Earlier on Saturday the Israeli army gave the Al-Shifa hospital one hour to evacuate as concerns persist over doctors' ability to move critically ill patients southwards without the use of ambulances.
According to the United Nations, some 2,300 people remain at the hospital, many of whom are displaced persons seeking shelter from other areas of north Gaza.
According to Al Jazeera some 300 patients are in the hospital, many of which are in critical condition, with doctors at the hospital saying "the Israeli army has not provided them with any other solutions" nor means to evacuate the hospital.
The Israeli military has denied the claims.
The evacuation order comes as Israeli airstrikes continue to devastate central and southern Gaza, which the Israeli army has designated a non-combat zone where Gazans can flee.
Two Israeli airstrikes that struck the city of Khan Younis this morning killed 28 people, with dozens injured and buried under the rubble. Another airstrike in Deir el-Balah in central Gaza killed six, with many others wounded.
Since the start of Israel's siege and bombardment of Gaza, 12,000 people have been killed, including over 5,000 children.